人明胶酶（IV型胶原酶，基质金属蛋白酶-9）和金属蛋白酶组织抑制剂1在黑利-黑利病及毛囊角化病中的免疫定位
Immunolocalization of human gelatinase (type IV collagenase, MMP-9) and tissue inhibitor of metalloproteinase 1 in Hailey-Hailey and Darier's diseases.
作者信息
Kobayashi T, Sakuraoka K, Hattori S, Hori H, Nagai Y, Tajima S, Nishikawa T
机构信息
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
出版信息
Dermatology. 1996;193(2):110-4. doi: 10.1159/000246223.
BACKGROUND
The formation of lacunae and acantholysis as well as dyskeratosis are characteristic features of Hailey-Hailey disease (HHD) and Darier's disease (DD). Matrix metalloproteinases (MMPs) and their inhibitors like tissue inhibitors of metalloproteinases (TIMPs) have been thought to play major roles in the tissue metabolism.
OBJECTIVE
The aim of this study was to investigate the role of MMP-9 and TIMP-1 in HHD and DD.
METHODS
We examined localizations of these two molecules by immunostaining using specific monoclonal antibodies.
RESULTS
MMP-9 was positively stained in dyskeratotic or detaching cells around lacunae in HHD and DD. TIMP-1 showed a positive staining pattern throughout the epidermis.
CONCLUSION
MMP-9 might be involved in the pathophysiological process of HHD and DD in the presence of TIMP-1.
背景
腔隙形成、棘层松解以及角化不良是Hailey-Hailey病（HHD）和 Darier病（DD）的特征性表现。基质金属蛋白酶（MMPs）及其抑制剂如金属蛋白酶组织抑制剂（TIMPs）被认为在组织代谢中起主要作用。
目的
本研究旨在探讨MMP-9和TIMP-1在HHD和DD中的作用。
方法
我们使用特异性单克隆抗体通过免疫染色检查这两种分子的定位。
结果
在HHD和DD中，MMP-9在腔隙周围的角化不良或分离细胞中呈阳性染色。TIMP-1在整个表皮呈现阳性染色模式。
结论
在TIMP-1存在的情况下，MMP-9可能参与HHD和DD的病理生理过程。
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