Lazaros G A, Stavrinos C, Papatheodoridis G V, Delladetsima J K, Toliopoulos A, Tassopoulos N C
First Department of Medicine, Western Attica General Hospital, Athens, Greece.
Hepatogastroenterology. 1996 Jul-Aug;43(10):1015-9.
Two cases of amineptine induced liver injury in patients treated with the drug for 18 and 15 days respectively, are reported. Hepatic reaction lasted 60 days in the first case and 120 days in the second one, with the latter considered unusually prolonged. The patients history, the course of the reaction and the histologic findings were compatible with the diagnosis of drug induced liver disease in both cases. Furthermore, every other possible origin of hepatobiliary injury such as disorders of bile ducts, ongoing viral hepatitis and autoimmune hepatitis were excluded. The mechanism of amineptine induced liver injury and the influence of a possible genetic predisposition to amineptine hepatotoxicity are also discussed.
报告了两例分别服用阿米替林18天和15天的患者发生的药物性肝损伤。第一例患者的肝反应持续了60天，第二例持续了120天，后者被认为持续时间异常延长。两例患者的病史、反应过程和组织学检查结果均符合药物性肝病的诊断。此外，排除了其他所有可能导致肝胆损伤的原因，如胆管疾病、正在发作的病毒性肝炎和自身免疫性肝炎。还讨论了阿米替林所致肝损伤的机制以及可能的遗传易感性对阿米替林肝毒性的影响。
