Morosini P P, Taccaliti A, Montironi R, Diamanti L, Scarpelli M, Simonella G, Mancini V, Petrelli M D, Fabris G, Mantero F
Clinica di Endocrinologia, Istituto di Medicina Clinica, Ancona, Italy.
J Endocrinol Invest. 1996 Jul-Aug;19(7):422-6. doi: 10.1007/BF03349886.
To investigate whether the immunohistochemical pattern of TGF beta 1 may be a marker of relapse for adenomatous pathology, 18 follicular adenomas, surgically removed by hemithyroidectomy between 1977 and 1982, were studied. The adenomas were divided into two groups according to the presence (group 1, N = 9) or absence (group 2, N = 9) of nodules recurring in the residual thyroid tissue. The presence and location of TGF beta 1 were evaluated a posteriori by immunohistochemistry in the removed adenoma. Fifty randomly selected subcapsular follicles were studied in each adenoma in order to evaluate the percentage of positive follicles and TGF beta 1 intra-thyrocyte location. In adenoma of group 1, the percentage of positive follicles for TGF beta 1 was lower (80%) than in adenoma of group 2 (84%); this was, however, not statistically significant. The location of TGF beta 1 was mainly at the cell base of the epithelial cells in the microfollicles of group 1, but was dominant at the cell apex in group 2 (p < 0.01). In conclusion, adenoma recurrence is independent of TGF beta 1 production; it may be due to an abnormal TGF beta 1 regulation in response to hyperplasiogenic stimuli.
为了研究转化生长因子β1（TGFβ1）的免疫组化模式是否可能是腺瘤性病变复发的标志物，我们对1977年至1982年间通过甲状腺半切除术手术切除的18个滤泡性腺瘤进行了研究。根据残余甲状腺组织中是否存在结节（第1组，N = 9）或不存在结节（第2组，N = 9）将腺瘤分为两组。通过免疫组化对切除的腺瘤中TGFβ1的存在和位置进行事后评估。在每个腺瘤中研究50个随机选择的包膜下滤泡，以评估阳性滤泡的百分比和TGFβ1在甲状腺细胞内的位置。在第1组腺瘤中，TGFβ1阳性滤泡的百分比（80%）低于第2组腺瘤（84%）；然而，这在统计学上并不显著。TGFβ1的位置在第1组微滤泡上皮细胞的细胞基部为主，但在第2组中在细胞顶端占主导（p < 0.01）。总之，腺瘤复发与TGFβ1的产生无关；它可能是由于对增生性刺激的异常TGFβ1调节所致。
