Gagne J M, Weiss D J, Armstrong P J
Department of Veterinary Pathobiology, University of Minnesota College of Veterinary Medicine, Saint Paul, USA.
Vet Pathol. 1996 Sep;33(5):521-6. doi: 10.1177/030098589603300506.
To better define the histopathologic features of feline inflammatory liver disease, we studied feline liver biopsies evaluated at the University of Minnesota Veterinary Teaching Hospital over a 10-year period. Of 175 liver sections examined, 45 had portal inflammatory infiltrates. Of these, 60% had infiltrates consisting of lymphocytes and plasma cells, 24% had infiltrates consisting of neutrophils, and 16% had mixed infiltrates consisting of neutrophils, lymphocytes, and plasma cells. Lymphocytic-plasmacytic portal infiltrates were characterized by various degrees of bile duct proliferation and fibrosis without evidence of bile duct infiltration or periportal necrosis. Sections with portal neutrophilic infiltrates were characterized by bile duct infiltration, bile duct epithelial degeneration, periportal necrosis, and infiltration of neutrophils into adjacent lobules. We propose that hepatitis characterized by portal lymphocyte and plasma cell infiltration be termed lymphocytic portal hepatitis and that hepatitis characterized by cholangitis and portal neutrophilic infiltrates with or without lymphocytes and plasma cells be termed cholangiohepatitis.
为了更好地界定猫炎性肝病的组织病理学特征，我们研究了明尼苏达大学兽医学院教学医院在10年期间评估的猫肝脏活检样本。在检查的175个肝脏切片中，45个有门管区炎性浸润。其中，60%的浸润由淋巴细胞和浆细胞组成，24%的浸润由中性粒细胞组成，16%的浸润由中性粒细胞、淋巴细胞和浆细胞混合组成。淋巴细胞-浆细胞门管区浸润的特征是不同程度的胆管增生和纤维化，无胆管浸润或门管区周围坏死的证据。有门管区中性粒细胞浸润的切片的特征是胆管浸润、胆管上皮变性、门管区周围坏死以及中性粒细胞浸润至相邻小叶。我们建议将以门管区淋巴细胞和浆细胞浸润为特征的肝炎称为淋巴细胞性门管区肝炎，将以胆管炎和门管区中性粒细胞浸润（伴有或不伴有淋巴细胞和浆细胞）为特征的肝炎称为胆管性肝炎。
