西替利嗪对被动致敏豚鼠抗原诱导气管收缩的影响。

Effect of cetirizine on antigen-induced tracheal contraction of passively sensitized guinea pigs.

作者信息

Dobashi K, Iizuka K, Houjou S, Sakai H, Watanabe K, Mori M, Nakazawa T

机构信息

First Department of Internal Medicine, Gunma University, School of Medicine, Japan.

出版信息

Ann Allergy Asthma Immunol. 1996 Oct;77(4):310-8. doi: 10.1016/S1081-1206(10)63326-1.

DOI:10.1016/S1081-1206(10)63326-1

PMID:8885809

Abstract

BACKGROUND

Cetirizine dihydrochloride (cetirizine), a potent histamine H1-receptor antagonist, has been developed as an anti-allergy drug.

OBJECT

The anti-allergic effects and mechanism of cetirizine were studied using in vitro assay systems.

METHODS

We investigated the effect of cetirizine on antigen-induced contractions of isolated tracheal strips and on chemical mediator release from antigen-stimulated lung chips taken from passively sensitized guinea pigs. We examined the antigen-induced mobilization of Ca2+ in MC/9 mast cells sensitized with IgE.

RESULTS

Cetirizine inhibited the antigen-induced contraction of isolated guinea-pig trachea concentration dependently. Pyrilamine, another histamine H1-receptor antagonist, delayed the response but did not change the maximum amplitude. Cetirizine at the concentration of 3 microM also inhibited the antigen-induced release of histamine, leukotriene D4, and leukotriene E4 from guinea pig lung chips. Furthermore, it inhibited the antigen-induced Ca2+ increase in MC/9 mast cells, whereas pyrilamine did not.

CONCLUSION

These findings suggest that one anti-allergic mechanism of cetirizine may inhibit mediator release which is, at least partially, mediated by a decrease in the transient Ca2+ influx in mast cells.

摘要