Salmon E, Meulemans T, van der Linden M, Degueldre C, Franck G
Department of Neurology, University of Liège, Belgium.
Acta Neurol Belg. 1996 Sep;96(3):247-53.
We report neuropsychological and neuroimaging investigations performed in a patient suffering from presenile onset degenerative dementia and subsequent mild extrapyramidal and pyramidal signs. Early neuropsychological testing revealed frontal lobe dysfunction. Neuroanatomical pictures were not contributive. After four years of evolution, the clinical pattern was consistent with progressive supranuclear palsy. Statistical parametric mapping analysis of functional imaging revealed a highly significant metabolic impairment in the anterior cingulate gyrus, that might be a key feature of subcortico-frontal dementia in progressive supranuclear palsy.
我们报告了对一名患有早发性退行性痴呆及随后出现轻度锥体外系和锥体体征的患者进行的神经心理学和神经影像学研究。早期神经心理学测试显示额叶功能障碍。神经解剖图像并无帮助。经过四年的病情发展，临床症状符合进行性核上性麻痹。功能成像的统计参数映射分析显示前扣带回存在高度显著的代谢损害，这可能是进行性核上性麻痹所致皮质下额叶痴呆的关键特征。
