多巴胺DRD2/Cys311与慢性精神分裂症无关。
Dopamine DRD2/Cys311 is not associated with chronic schizophrenia.
作者信息
Crawford F, Hoyne J, Cai X, Osborne A, Poston D, Zaglul J, Dajani N, Walsh S, Bradley R, Solomon R, Mullan M
机构信息
Roskamp Laboratories, University of South Florida, Tampa 33613, USA.
出版信息
Am J Med Genet. 1996 Sep 20;67(5):483-4. doi: 10.1002/(SICI)1096-8628(19960920)67:5<483::AID-AJMG8>3.0.CO;2-L.
A mutation in the DRD2 receptor gene has been reported in association with schizophrenia in Japanese and Caucasian populations. The variation, Ser to Cys at codon 311, occurs in the third intracellular loop of the receptor and is therefore putatively functional. We report the results of screening US Caucasian schizophrenic and nonschizophrenic populations. We detected the occurrence of the DRD2 Cys311 variant in both schizophrenics and controls. Our data demonstrates no significant difference between the frequency of Cys311 in Caucasian schizophrenic and non-schizophrenic populations, indicating no association with schizophrenia.
据报道，在日本和高加索人群中，DRD2受体基因的一种突变与精神分裂症有关。该变异发生在受体的第三个细胞内环中，为密码子311处的丝氨酸突变为半胱氨酸，因此推测具有功能。我们报告了对美国高加索精神分裂症患者和非精神分裂症患者群体进行筛查的结果。我们在精神分裂症患者和对照组中均检测到了DRD2 Cys311变体的出现。我们的数据表明，高加索精神分裂症患者和非精神分裂症患者群体中Cys311的频率没有显著差异，这表明该变体与精神分裂症没有关联。
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