假定的精神分裂症基因座D6S260与双相情感障碍无连锁关系。

Nonlinkage of D6S260, a putative schizophrenia locus, to bipolar affective disorder.

作者信息

Adams L J, Salmon J, Donald J A, Mitchell P B, Schofield P R

机构信息

School of Psychiatry, University of New South Wales, Little Bay, New South Wales, Australia.

出版信息

Am J Med Genet. 1996 Sep 20;67(5):485-7. doi: 10.1002/(SICI)1096-8628(19960920)67:5<485::AID-AJMG9>3.0.CO;2-J.

DOI:10.1002/(SICI)1096-8628(19960920)67:5<485::AID-AJMG9>3.0.CO;2-J

PMID:8886167

Abstract

To examine whether genes that predispose to schizophrenia also confer a predisposition to other psychiatric disorders such as bipolar affective disorder (BAD), we tested for linkage between the recently identified schizophrenia susceptibility locus D6S260 and the inheritance of BAD in 12 large Australian pedigrees. We found no evidence for linkage over a region of 12-27 cM from the D6S260 locus, depending on the model used. Our results therefore do not provide support for the continuum theory of psychosis.

摘要

为了研究导致精神分裂症的基因是否也会使人易患其他精神疾病，如双相情感障碍（BAD），我们在12个澳大利亚大家庭中，对最近确定的精神分裂症易感基因座D6S260与双相情感障碍的遗传之间进行了连锁分析。根据所使用的模型，我们发现在距离D6S260基因座12-27厘摩的区域内没有连锁的证据。因此，我们的结果不支持精神病的连续性理论。