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鉴定DL-苏型二氢神经鞘氨醇和神经鞘氨醇为气道平滑肌细胞外信号调节激酶信号传导的新型抑制剂。

The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle.

作者信息

Tolan D, Conway A M, Steele L, Pyne S, Pyne N J

机构信息

Department of Physiology and Pharmacology, University of Strathclyde, Glasgow.

出版信息

Br J Pharmacol. 1996 Sep;119(2):185-6. doi: 10.1111/j.1476-5381.1996.tb15967.x.

DOI:10.1111/j.1476-5381.1996.tb15967.x
PMID:8886394
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1915874/
Abstract

We present entirely novel evidence that DL-threo dihydrosphingosine and sphingosine are inhibitors of the extracellular signal-regulated kinase (ERK) signalling cassette in mammalian cells. We show that DL-threo dihydrosphingosine is effective against both growth factor- and G-protein-dependent activation of ERK. We conclude that DL-threo dihydrosphingosine may represent an important pharmacological cell-permeable agent that may be usefully employed to block smooth muscle cell proliferation.

摘要

我们提供了全新的证据，表明DL-苏式二氢鞘氨醇和鞘氨醇是哺乳动物细胞中细胞外信号调节激酶（ERK）信号转导盒的抑制剂。我们发现DL-苏式二氢鞘氨醇对生长因子和G蛋白依赖性的ERK激活均有效。我们得出结论，DL-苏式二氢鞘氨醇可能是一种重要的具有细胞通透性的药理试剂，可用于阻止平滑肌细胞增殖。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8673/1915874/b83223596778/brjpharm00071-0010-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8673/1915874/b83223596778/brjpharm00071-0010-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8673/1915874/b83223596778/brjpharm00071-0010-a.jpg

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The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle.鉴定DL-苏型二氢神经鞘氨醇和神经鞘氨醇为气道平滑肌细胞外信号调节激酶信号传导的新型抑制剂。
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本文引用的文献

1
Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase 2 (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscle.鞘磷脂衍生脂质以不同方式调节气道平滑肌中的细胞外信号调节激酶2（ERK-2）和c-Jun氨基末端激酶（JNK）信号级联反应。
Eur J Biochem. 1996 May 1;237(3):819-26. doi: 10.1111/j.1432-1033.1996.0819p.x.
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The differential regulation of cyclic AMP by sphingomyelin-derived lipids and the modulation of sphingolipid-stimulated extracellular signal regulated kinase-2 in airway smooth muscle.鞘磷脂衍生脂质对环磷酸腺苷的差异调节以及气道平滑肌中鞘脂刺激的细胞外信号调节激酶-2的调控
Biochem J. 1996 May 1;315 ( Pt 3)(Pt 3):917-23. doi: 10.1042/bj3150917.
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Biochem J. 2000 Jul 15;349(Pt 2):385-402. doi: 10.1042/0264-6021:3490385.
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缓激肽可刺激豚鼠气管平滑肌原代培养物中的磷脂酶D。
Biochem Pharmacol. 1993 Feb 9;45(3):593-603. doi: 10.1016/0006-2952(93)90132-g.
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Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens.鞘氨醇-1-磷酸作为血小板衍生生长因子（PDGF）和胎牛血清（FCS）促细胞分裂剂诱导细胞增殖过程中的第二信使。
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