收缩性激动剂对大鼠离体肠系膜动脉内皮依赖性舒张机制的影响。
Influence of contractile agonists on the mechanism of endothelium-dependent relaxation in rat isolated mesenteric artery.
作者信息
Plane F, Garland C J
机构信息
Department of Pharmacology, University of Bristol.
出版信息
Br J Pharmacol. 1996 Sep;119(2):191-3. doi: 10.1111/j.1476-5381.1996.tb15970.x.
Abstract
This study demonstrates directly that the relative contribution of nitric oxide (NO) and an NO synthase-independent repolarization to acetylcholine-evoked relaxation in rat isolated mesenteric resistance arteries is determined by the processes which mediate pre-contraction. Noradrenaline-induced contractions were reversed by acetylcholine via both NO and NO synthase-independent smooth muscle repolarization. In contrast, reversal of contractions to the thromboxane-mimetic, U46619, by acetylcholine was entirely mediated by the actions of NO, independently of a change in membrane potential.
摘要
本研究直接表明，在大鼠离体肠系膜阻力动脉中，一氧化氮（NO）和不依赖一氧化氮合酶的复极化对乙酰胆碱诱发的舒张的相对贡献，由介导预收缩的过程决定。去甲肾上腺素诱导的收缩可被乙酰胆碱通过NO和不依赖一氧化氮合酶的平滑肌复极化逆转。相比之下，乙酰胆碱对血栓素类似物U46619诱导的收缩的逆转完全由NO的作用介导，与膜电位变化无关。
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本文引用的文献
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Evidence for mediation by endothelium-derived hyperpolarizing factor of relaxation to bradykinin in the bovine isolated coronary artery independently of voltage-operated Ca2+ channels.在牛离体冠状动脉中，内皮衍生超极化因子介导对缓激肽的舒张作用的证据，该作用独立于电压门控Ca2+通道。
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Noradrenaline contracts arteries by activating voltage-dependent calcium channels.去甲肾上腺素通过激活电压依赖性钙通道使动脉收缩。
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