Lavergne N, Aristizabal J, Zarka V, Erny R, Hedon B
Hôpital de la Conception CPMA, Marseille, France.
Eur J Obstet Gynecol Reprod Biol. 1996 Sep;68(1-2):29-34. doi: 10.1016/0301-2115(96)02459-1.
To evaluate the influence of uterine anomalies on the implantation rates after embryo transfer.
A retrospective, multicentric study. This study compare patients presenting a uterine anomaly (septate uterus, umicornuate, pseudonicornuate, bicornuate uterus) having attempted FIVETE between 1987 and 1992 with the normal population treated by IVF, as well as with FIVNAT results.
Thirty-eight patients were part of the studied population and total 119 oocyt retrievals which lead to 103 embryo transfers (corresponding to 1.35% of the realised transfers during the same period in the three centers of the study). The pregnancy rate obtained by these patients is significantly lower than those obtained by the control group (11.7% pregnancies by retrievals vs. 19.1%, and 13.6% pregnancies by transfer vs. 24.9%). The implantation rate by embryo transfer is 5.8% in the population studied vs. 11.7% in the control group (P < 0.01). These results significantly improve when the uterine anomaly can be treated (septate uterus).
The uterine anomalies are associated with a lowered rate of embryo implantation. This implantation rate improves when the anomaly can be treated (septate uterus).
评估子宫异常对胚胎移植后着床率的影响。
一项回顾性多中心研究。本研究比较了1987年至1992年间尝试进行卵胞浆内单精子注射胚胎移植（FIVETE）的子宫异常患者（纵隔子宫、单角子宫、假单角子宫、双角子宫）与接受体外受精（IVF）治疗的正常人群，以及与卵胞浆内单精子注射自然周期胚胎移植（FIVNAT）的结果。
38名患者纳入研究人群，共进行了119次取卵，导致103次胚胎移植（占研究中三个中心同期实际移植的1.35%）。这些患者获得的妊娠率显著低于对照组（取卵后的妊娠率为11.7%，对照组为19.1%；移植后的妊娠率为13.6%，对照组为24.9%）。研究人群中胚胎移植的着床率为5.8%，而对照组为11.7%（P<0.01）。当子宫异常可以治疗时（纵隔子宫），这些结果有显著改善。
子宫异常与胚胎着床率降低有关。当异常可以治疗时（纵隔子宫），着床率会提高。
