促性腺激素释放激素激动剂疗法可诱导子宫平滑肌瘤细胞凋亡。

Gonadotropin-releasing hormone agonist therapy induces apoptosis in uterine leiomyoma.

作者信息

Higashijima T, Kataoka A, Nishida T, Yakushiji M

机构信息

Department of Obstetrics and Gynecology, Kurume University School of Medicine, Japan.

出版信息

Eur J Obstet Gynecol Reprod Biol. 1996 Sep;68(1-2):169-73. doi: 10.1016/0301-2115(96)02504-3.

DOI:10.1016/0301-2115(96)02504-3

PMID:8886702

Abstract

OBJECTIVE

We examined uterine tissue samples obtained from premenopausal women with uterine leiomyoma treated with gonadotropin-releasing hormone agonist (GnRHa) to investigate the mechanism of the effects of GnRHa.

STUDY DESIGN

Surgically resected myoma tissue obtained from 26 premenopausal patients with uterine leiomyoma treated with GnRHa, 20 premenopausal patients with uterine leiomyoma who did not receive GnRHa treatment, and 15 postmenopausal women with uterine leiomyoma were examined histologically.

RESULTS

GnRHa treatment reduced the size of uterine leiomyomata and induced significant hyaline degeneration in tumor tissue. Le(Y)-antigen expression was detected in 18 (69.3%) of 26 GnRHa-treated patients (P < 0.02) and in 12 (80.0%) of 15 postmenopausal women (P < 0.05), but in only eight (40.0%) of the 20 premenopausal patients who did not receive GnRHa. Apoptotic cells, detected by the nick-end labeling method were observed in 14 patients (53.8%) in the GnRHa-treated group, 10 patients (50.0%) in the non-treated group, and 12 postmenopausal women (80.0%).

CONCLUSION

Our findings suggest that induction of apoptosis may be a mechanism of the effect of GnRHa in leiomyoma.

摘要

目的

我们检查了从接受促性腺激素释放激素激动剂（GnRHa）治疗的绝经前子宫肌瘤女性获取的子宫组织样本，以研究GnRHa作用的机制。

研究设计

对26例接受GnRHa治疗的绝经前子宫肌瘤患者、20例未接受GnRHa治疗的绝经前子宫肌瘤患者以及15例绝经后子宫肌瘤女性手术切除的肌瘤组织进行组织学检查。

结果

GnRHa治疗减小了子宫肌瘤的大小，并在肿瘤组织中诱导了显著的透明变性。在26例接受GnRHa治疗的患者中有18例（69.3%）检测到Le(Y)抗原表达（P<0.02），在15例绝经后女性中有12例（80.0%）检测到（P<0.05），但在20例未接受GnRHa治疗的绝经前患者中只有8例（40.0%）检测到。通过缺口末端标记法检测到凋亡细胞，在GnRHa治疗组的14例患者（53.8%）、未治疗组的10例患者（50.0%）以及12例绝经后女性（80.0%）中观察到。