Kurita Y, Ushiyama T, Suzuki K, Fujita K, Kawabe K
Department of Urology, Hamamatsu University School of Medicine, Japan.
Int J Urol. 1996 Sep;3(5):361-6. doi: 10.1111/j.1442-2042.1996.tb00554.x.
The aim of the present study was to determine whether the indices of transrectal ultrasonography (TRUS) are related to the clinical response to tamsulosin, a long-acting selective alpha 1-blocker.
Sixty patients with symptomatic benign prostatic hypertrophy (BPH) were treated with tamsulosin hydrochloride (0.2 mg/day) for 2 months. The findings on TRUS and uroflowmetry and the AUA symptom score before treatment were compared with those obtained at the end of the 2 month treatment period. For the indices of TRUS, transition zone (TZ) volume, transition zone ratio (TZ ratio = TZ volume/total prostate volume), total prostate volume, and prostate specific antigen density (PSAD) were calculated.
There was a significant correlation between the pretreatment TZ ratio and the residual urine volume (r = 0.421, P = 0.0005). Patients with a lower TZ ratio and/or PSAD responded well to the treatment. The correlation between the PSAD value and the percent change in peak urinary flow rate was statistically significant (r = -0.432, P = 0.0009).
TRUS provides simple parameters of PSAD that can be used to predict the response of patients to tamsulosin hydrochloride.
本研究的目的是确定经直肠超声检查（TRUS）指标是否与长效选择性α1受体阻滞剂坦索罗辛的临床反应相关。
60例有症状的良性前列腺增生（BPH）患者接受盐酸坦索罗辛（0.2mg/天）治疗2个月。将治疗前TRUS和尿流率检查结果及美国泌尿外科学会（AUA）症状评分与2个月治疗期结束时获得的结果进行比较。对于TRUS指标，计算移行区（TZ）体积、移行区比例（TZ比例=TZ体积/前列腺总体积）、前列腺总体积和前列腺特异抗原密度（PSAD）。
治疗前TZ比例与残余尿量之间存在显著相关性（r=0.421，P=0.0005）。TZ比例较低和/或PSAD较低的患者对治疗反应良好。PSAD值与最大尿流率变化百分比之间的相关性具有统计学意义（r=-0.432，P=0.0009）。
TRUS提供了简单的PSAD参数，可用于预测患者对盐酸坦索罗辛的反应。
