Fujiwara K, Sakai Y, Sugiura J, Yamasaki A
Department of Oral Pathology, Ohu University School of Dentistry, Koriyama, Japan.
J Oral Pathol Med. 1996 Jul;25(6):314-9. doi: 10.1111/j.1600-0714.1996.tb00269.x.
To facilitate recognition of the oral mucosal lesion that develops in rats with graft-versus-host disease (GVHD) induced by injecting spleen cells of parental strain rats (Brown Norway) into non-irradiated (Brown Norway x Lewis) F1 hybrid rats, we followed the development of the tongue lesion histologically and immunohistochemically. This assessment revealed an increase in the number of MHC class II+ cells with dendritic shape in the lamina propria to be the earliest stage of the tongue lesions in GVHD rats. The subsequent mononuclear cell infiltration with epithelial cell destruction, characteristic of GVHD, consisted of CD8+ cells and macrophages. Our findings seem to indicate that MHC class II+ cells with dendritic shape may provide antigen presentation in the induction of local immunological responses, including tissue destruction, by CD8+ cells and macrophages in the tongue of GVHD rats.
为便于识别通过将亲代品系大鼠（棕色挪威大鼠）的脾细胞注射到未受辐照的（棕色挪威大鼠×刘易斯大鼠）F1杂交大鼠中诱导的移植物抗宿主病（GVHD）大鼠所发生的口腔黏膜病变，我们对舌部病变进行了组织学和免疫组织化学观察。该评估显示，固有层中具有树突状形态的MHC II类阳性细胞数量增加是GVHD大鼠舌部病变的最早阶段。随后出现的以上皮细胞破坏为特征的单核细胞浸润，这是GVHD的典型表现，浸润细胞包括CD8阳性细胞和巨噬细胞。我们的研究结果似乎表明，具有树突状形态的MHC II类阳性细胞可能在诱导局部免疫反应（包括GVHD大鼠舌部CD8阳性细胞和巨噬细胞引起的组织破坏）中发挥抗原呈递作用。
