J Reprod Med. 1996 Sep;41(9):665-70.
To investigate epidemiologic, clinical and pathologic aspects of various grades of vulvar intraepithelial neoplasia (VIN).
A retrospective, multicenter study of 370 cases of vulvar intraepithelial neoplasia (VIN) was performed by the Italian Study Group on Vulvar Disease.
Of the 370 cases, 148 were VIN 1 (40.0%, 53 were VIN 2 (14.3%), and 169 were VIN 3 (45.7%). The mean age of the patients was 52.6 years. During the study period an increase in the rate of human papillomavirus-associated VIN was observed. In addition, while VIN 1 and 2 were associated mostly with squamous cell hyperplasia, VIN 3 was almost equally associated with lichen sclerosus and squamous cell hyperplasia; the difference was statistically significant. Intraepithelial or invasive squamous neoplasia of the lower genital tract was associated in 22% of the cases (82/370).
The results of the investigation, although not allowing firm conclusions due to the retrospective and multicentered nature of the study, demonstrate the extreme heterogeneity of VIN lesions.
探讨不同级别外阴上皮内瘤变（VIN）的流行病学、临床及病理特征。
意大利外阴疾病研究小组对370例外阴上皮内瘤变患者进行了一项回顾性多中心研究。
370例患者中，148例为VIN 1（40.0%），53例为VIN 2（14.3%），169例为VIN 3（45.7%）。患者的平均年龄为52.6岁。研究期间观察到人乳头瘤病毒相关VIN的发生率有所增加。此外，VIN 1和VIN 2主要与鳞状细胞增生相关，而VIN 3与硬化性苔藓和鳞状细胞增生的相关性几乎相同；差异具有统计学意义。22%的病例（82/370）伴有下生殖道上皮内或浸润性鳞状上皮瘤变。
尽管由于该研究的回顾性和多中心性质，无法得出确凿结论，但研究结果显示了VIN病变的极端异质性。
