Larijani G E, Goldberg M E, Rogers K H
Department of Anesthesiology, Cooper Hospital/UMC, Robert Wood Johnson Medical School at Camden, New Jersey 08103, USA.
Pharmacotherapy. 1996 Sep-Oct;16(5):958-60.
Pruritus is a common side effect after neuraxial administration of the opioids; particularly morphine sulfate. Ondansetron has been used to treat the pruritus in patients with cholestatic diseases or renal insufficiency, suggesting that pruritus may be mediated by serotonin. We administered ondansetron to four patients suffering from pruritus due to the perioperative administration of opioids. Pruritus disappeared within few minutes in three of these patients. Future studies are necessary to evaluate the efficacy of ondansetron for the treatment as well as the prevention of this opioid-induced effect.
瘙痒是阿片类药物经椎管内给药后的常见副作用；尤其是硫酸吗啡。昂丹司琼已被用于治疗胆汁淤积性疾病或肾功能不全患者的瘙痒，这表明瘙痒可能由5-羟色胺介导。我们对4例因围手术期使用阿片类药物而出现瘙痒的患者给予了昂丹司琼。其中3例患者的瘙痒在几分钟内消失。有必要进行进一步研究以评估昂丹司琼治疗以及预防这种阿片类药物所致效应的疗效。
