Bernardy N C, King A C, Parsons O A, Lovallo W R
Behavioral Sciences Laboratories, Veterans Affairs Medical Center, Oklahoma City, OK, USA.
Alcohol. 1996 Sep-Oct;13(5):493-8. doi: 10.1016/0741-8329(96)00043-2.
We have previously reported an attenuated plasma cortisol stress response in alcoholics abstinent from alcohol up to 4 weeks. The present study replicates and extends these findings by examining urinary cortisol levels in detoxified alcoholics (n = 40) and controls (n = 14) at rest and following mental arithmetic and isometric handgrip stress. Although the groups had similar baseline cortisol levels, the alcoholics showed an attenuated cortisol response to the combined stressors. This cortisol response reduction was unrelated to potential confounds such as smoking, liver function, age, depression, or anxiety. A multivariate model showed a trend for an association between severity of withdrawal and alcoholics' poststress cortisol levels. Although these results indicate decreased adrenocortical response to biobehavioral stress in alcoholics abstinent up to four weeks, higher stress cortisol values were seen in the patients with the most severe withdrawal symptoms.
我们之前曾报道，戒酒长达4周的酗酒者血浆皮质醇应激反应减弱。本研究通过检测40名戒酒者和14名对照组在静息状态下以及进行心算和等长握力应激后的尿皮质醇水平，重复并扩展了这些发现。尽管两组的基线皮质醇水平相似，但酗酒者对联合应激源的皮质醇反应减弱。这种皮质醇反应降低与吸烟、肝功能、年龄、抑郁或焦虑等潜在混杂因素无关。多变量模型显示，戒断严重程度与酗酒者应激后皮质醇水平之间存在关联趋势。尽管这些结果表明，戒酒长达四周的酗酒者肾上腺皮质对生物行为应激的反应降低，但在戒断症状最严重的患者中，应激皮质醇值更高。
