Head A, Kendall M J, Ferner R, Eagles C
Department of Medicine, University of Birmingham, United Kingdom.
Br J Sports Med. 1996 Sep;30(3):238-42. doi: 10.1136/bjsm.30.3.238.
To measure the previously reported beta blocker induced adverse changes in mood state and anxiety measures, and to determine if prolonged aerobic exercise attenuates such mood modifications.
After 4 days of drug treatment with comparable doses of propranolol (40 and 80 mg), metoprolol (50 and 100 mg), or placebo, mood (POMS) and anxiety states (STAI) were assessed in healthy volunteers, before and after 1 h of treadmill walking exercise at 50% maximum oxygen uptake.
Compared to placebo, resting "tension", "depression", and "total mood disturbance" were significantly higher on propranolol 80 mg, but all were reduced with exercise. "Fatigue" and "confusion" were also higher on propranolol, and were unaffected by exercise. "Fatigue" was also higher than placebo after exercise on metoprolol 100 mg. "Anxiety" was unaffected by drug treatment or exercise.
The evidence that beta blockers, and particularly propranolol, have adverse effects on mood was confirmed. It would be preferable to prescribe a beta blocker which does not adversely alter mood states. However, exercise significantly reduced the measures of "tension" and "depression" which were adversely increased by propranolol. Exercise prescription may therefore not only be compatible with beta blockade, but a highly desirable adjuvant therapy.
测量先前报道的β受体阻滞剂引起的情绪状态和焦虑指标的不良变化，并确定长期有氧运动是否能减轻此类情绪改变。
在健康志愿者接受4天可比剂量的普萘洛尔（40和80毫克）、美托洛尔（50和100毫克）或安慰剂药物治疗后，于最大摄氧量50%的跑步机上行走运动1小时前后，评估其情绪（POMS）和焦虑状态（STAI）。
与安慰剂相比，服用80毫克普萘洛尔时静息状态下的“紧张”“抑郁”和“总体情绪紊乱”显著更高，但运动后均有所降低。普萘洛尔组的“疲劳”和“困惑”也更高，且不受运动影响。服用100毫克美托洛尔运动后“疲劳”也高于安慰剂。“焦虑”不受药物治疗或运动的影响。
证实了β受体阻滞剂，尤其是普萘洛尔，对情绪有不良影响。最好开具不会对情绪状态产生不利影响的β受体阻滞剂。然而，运动显著降低了普萘洛尔导致的“紧张”和“抑郁”指标。因此，运动处方不仅可能与β受体阻滞剂治疗兼容，而且是一种非常理想的辅助治疗方法。
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