Kokudo N, Horimoto H, Ishida K, Takahashi S, Nozawa M
Department of Surgery, Meikai University, Saitama, Japan.
Cell Transplant. 1996 Sep-Oct;5(5 Suppl 1):S21-2. doi: 10.1016/0963-6897(96)00033-4.
Allogeneic hepatocyte and fetal liver transplantation and xenogeneic hepatocyte transplantation were performed in Nagase's analbuminemic (NAR, RT1(1)) rats, and the functional and morphological changes of intrasplenic grafts under FK506 immunosuppression were examined. Normal male Wistar Shi rats (RT1k) and male BALB/C mice were used as donors. Serum albumin levels in FK506-treated NAR rats 4 wk after all three transplantation techniques performed were significantly higher than those in animals without immunosuppression, indicating the intrasplenic grafts had survived in FK506-treated groups. On histological examination, hepatocyte colonies were detected in FK506-treated rats after allogeneic hepatocyte or fetal liver transplantation. NAR rats are expected to be useful for studies on allogeneic or xenogeneic hepatocyte transplantation under immunosuppression by various methods.
