Suarez S S
Department of Anatomy, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA.
J Androl. 1996 Jul-Aug;17(4):331-5.
The functions of hyperactivation may fit together to create the following scenario. Sperm that enter the oviduct bind to the mucosal epithelium. Near the time of ovulation, hyperactivation helps them to detach from the epithelium, escape mucosal pockets, and move through oviductal mucus. As sperm reach the ampulla, frequent changes in direction may enable them to encounter the cumulus mass. Then, hyperactivation assists them in penetrating the cumulus matrix and, after acrosome reacting, the zona pellucida. A factor or factors in the periovulatory oviduct or follicular fluid may induce hyperactivation by raising intracellular calcium levels in sperm. Knowledge of mechanisms regulating hyperactivation may be used to develop new clinical tests for fertility of semen samples.
超活化的功能可能共同作用，形成以下情形。进入输卵管的精子与黏膜上皮结合。在排卵临近时，超活化帮助它们从上皮脱离，逃离黏膜隐窝，并穿过输卵管黏液。当精子到达壶腹部时，频繁的方向改变可能使它们遇到卵丘团块。然后，超活化帮助它们穿透卵丘基质，并在顶体反应后穿透透明带。排卵周围输卵管或卵泡液中的一种或多种因素可能通过提高精子细胞内钙水平来诱导超活化。了解调节超活化的机制可用于开发新的精液样本生育能力临床检测方法。
