Thompson K H, Scott K C, Turnlund J R
United States Department of Agriculture/Agricultural Research Station, Western Human Nutrition Research Center, Presidio of San Francisco, California 94129-0997, USA.
J Appl Physiol (1985). 1996 Sep;81(3):1404-9. doi: 10.1152/jappl.1996.81.3.1404.
Molybdenum metabolism was studied in four young men to determine the effect of the amount of dietary molybdenum on molybdenum kinetics. A compartmental model, developed by using data from a study with low dietary molybdenum, was adapted to accommodate five levels of molybdenum. Each level, ranging from 22 to 1,470 micrograms molybdenum/day, was fed for 24 days. Kinetics of absorption and excretion were traced by using 97Mo (intravenous) and 100 Mo (oral) stable-isotope tracers at selected intervals. Urinary and fecal isotope excretion data for 6-day pooled collections were fit to a kinetic model by using SAAM/CONSAM software. Residence times for molybdenum were estimated at 2.4 days in the gastrointestinal tract, 40 min in plasma, from 3.3 to 0.3 days in fast-turnover tissue, and from 63 to 237 days in slow-turnover tissue. As dietary molybdenum increased, residence time decreased in fast-turnover tissue and increased in slow-turnover tissue. The model closely approximated the highly efficient homeostatic mechanisms of molybdenum metabolism over a wide range of intakes.
对四名年轻男性的钼代谢进行了研究，以确定膳食钼摄入量对钼动力学的影响。通过利用低膳食钼研究的数据建立的一个房室模型，被调整以适应五种钼水平。每种水平的钼摄入量从每天22微克到1470微克不等，每种水平的膳食持续供应24天。在选定的时间间隔内，使用97Mo（静脉注射）和100Mo（口服）稳定同位素示踪剂追踪吸收和排泄的动力学。利用SAAM/CONSAM软件，将6天汇总收集的尿液和粪便同位素排泄数据拟合到一个动力学模型中。估计钼在胃肠道的停留时间为2.4天，在血浆中为40分钟，在快速周转组织中为3.3至0.3天，在缓慢周转组织中为63至237天。随着膳食钼摄入量的增加，快速周转组织中的停留时间减少，而缓慢周转组织中的停留时间增加。该模型在很宽的摄入量范围内都能很好地模拟钼代谢的高效稳态机制。
