中性粒细胞在控制沙眼衣原体感染早期阶段中的作用。
Role of neutrophils in controlling early stages of a Chlamydia trachomatis infection.
作者信息
Barteneva N, Theodor I, Peterson E M, de la Maza L M
机构信息
Department of Pathology, University of California, Irvine 92697-4800, USA.
出版信息
Infect Immun. 1996 Nov;64(11):4830-3. doi: 10.1128/iai.64.11.4830-4833.1996.
Abstract
Inoculation of mice with the granulocyte-depleting monoclonal antibody RB6-8C5 showed that neutrophils are critical protective effector cells during a Chlamydia trachomatis infection. In addition, administration of monoclonal antibody 2E6 demonstrated that extravasation of neutrophils into the peritoneal cavity in response to inoculation with the C. trachomatis MoPn biovar is dependent on the surface beta-2 integrin molecule CD18.
摘要
用粒细胞耗竭单克隆抗体RB6 - 8C5接种小鼠表明，中性粒细胞是沙眼衣原体感染期间关键的保护性效应细胞。此外，给予单克隆抗体2E6表明，接种沙眼衣原体MoPn生物变种后，中性粒细胞向腹腔的渗出依赖于表面β - 2整合素分子CD18。
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Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody.一种粒细胞清除单克隆抗体显示，中性粒细胞对于肝脏早期抗李斯特菌防御至关重要，但对脾脏或腹腔的防御并非如此。
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Administration of anti-granulocyte mAb RB6-8C5 impairs the resistance of mice to Listeria monocytogenes infection.给予抗粒细胞单克隆抗体RB6-8C5会损害小鼠对单核细胞增生李斯特菌感染的抵抗力。
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