Stender I M, Wulf H C
Department of Dermatology, National University Hospital, Rigshospitalet, Copenhagen, Denmark.
Acta Derm Venereol. 1996 Sep;76(5):392-3. doi: 10.2340/0001555576392393.
We report a case of psoriasis reactivation following photodynamic therapy with delta-aminolevulinic acid. An 84-year-old women received several UVB treatment sessions because of severe psoriasis at her crura in the period from 1960 to 1990. Since then her psoriasis had been inactive. In 1994 she was admitted to our out-patient clinic because of multiple dysplastic lesions as well as multiple carcinomas at her crura. Surgical intervention was impossible and retinoids were not tolerated. She was treated with photodynamic therapy, which provoked a Købner reaction followed by a severe reactivation of the otherwise inactive psoriasis. Whether photodynamic therapy is used for the treatment of multiple dysplastic lesions in a psoriasis patient or for the treatment of psoriasis it seems important to be aware of this adverse effect. This is the first report of Købner reaction following photodynamic therapy.
我们报告了一例使用δ-氨基酮戊酸进行光动力治疗后银屑病复发的病例。一名84岁女性在1960年至1990年期间因双下肢严重银屑病接受了多次紫外线B治疗。从那时起，她的银屑病一直处于静止状态。1994年，她因双下肢多处发育异常病变以及多处癌症入住我们的门诊。手术干预不可能进行，且她不能耐受维甲酸类药物。她接受了光动力治疗，引发了同形反应，随后原本静止的银屑病严重复发。无论光动力治疗是用于治疗银屑病患者的多处发育异常病变还是用于治疗银屑病，意识到这种不良反应似乎都很重要。这是光动力治疗后发生同形反应的首例报告。
