Horger B A, Taylor J R, Elsworth J D, Jatlow P I, Roth R H
Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520-8066, USA.
Brain Res. 1996 Sep 9;733(1):133-7. doi: 10.1016/0006-8993(96)00783-4.
The present study assessed the ability of cocaethylene to induce sensitization to the behavioral activating effects of cocaine in the male Sprague-Dawley rat. Preexposure to cocaethylene (15 or 25 mg/kg) significantly enhanced the locomotor activating effects of a subsequent cocaine (15 mg/kg) challenge injection. In addition, acute intraperitonecal administration at several doses (10, 15, or 25 mg/kg) confirmed previous reports of increased bioavailability of cocaine in brain and plasma relative to cocaethylene. These data are discussed in terms of previous work in which a significant augmentation of cocaine-induced locomotor activity was not observed following cocaethylene preexposure.
