Turgan N, Coker C, Hamulu F, Elmaci S, Yilmaz C, Ersöz B, Işleğen C
Department of Clinical Biochemistry, Ege University School of Medicine, Bornova, Izmir, Turkey.
Eur J Clin Chem Clin Biochem. 1996 Sep;34(9):683-9. doi: 10.1515/cclm.1996.34.9.683.
Blood glucose, lactate, insulin, C-peptide, norepinephrine and epinephrine concentrations were determined in non-insulin-dependent diabetic patients and in healthy controls before, during and after moderate exercise, to evaluate the effects of physical exercise on glucoregulation. Ten diabetic and ten healthy control females bicycled 14 minutes at 60% of their maximal heart rates. In the diabetic patients, there were no significant changes in blood glucose levels post-exercise, while in controls the 60 minute post-exercise levels were higher than those measured in mid-exercise (p < 0.05). Lactate concentrations increased with exercise in both groups in a similar manner, with highest values at the end of exercise. No significant changes in insulin and C-peptide levels were induced with exercise in either group. Norepinephrine and epinephrine concentrations increased 2.5-3 fold with exercise in both groups (p < 0.05 for all values) but in the diabetics an earlier and prolonged catecholamine response was observed. We propose that catecholamines prevent hypoglycaemia during exercise when changes in insulin and C-peptide do not occur. In diabetic patients with good metabolic control, the glucoregulatory response to exercise is not worse than in anthropometrically similar controls with similar levels of fitness.
在非胰岛素依赖型糖尿病患者和健康对照者中，于适度运动前、运动期间和运动后测定血糖、乳酸、胰岛素、C肽、去甲肾上腺素和肾上腺素浓度，以评估体育锻炼对血糖调节的影响。10名糖尿病女性和10名健康对照女性以其最大心率的60%进行了14分钟的骑行。在糖尿病患者中，运动后血糖水平无显著变化，而在对照组中，运动后60分钟的血糖水平高于运动中期测得的血糖水平（p<0.05）。两组乳酸浓度均以相似方式随运动增加，在运动结束时达到最高值。两组运动均未引起胰岛素和C肽水平的显著变化。两组去甲肾上腺素和肾上腺素浓度均随运动增加2.5至3倍（所有值p<0.05），但糖尿病患者观察到儿茶酚胺反应更早且持续时间更长。我们认为，当胰岛素和C肽未发生变化时，儿茶酚胺可预防运动期间的低血糖。在代谢控制良好的糖尿病患者中，对运动的血糖调节反应并不比身体测量指标相似、健康水平相似的对照者差。
