金精三羧酸与三黄素在大鼠光化学诱导血栓形成模型中的协同作用
Synergistic effect of aurintricarboxylic acid and triflavin in a photochemically induced thrombosis model in rats.
作者信息
Hisamichi N, Kawasaki T, Suzuki K, Kaku S, Sakai Y, Taniuchi Y, Sato K, Inagaki O, Tomioka K, Yanagisawa I, Takenaka T, Yanagi K, Ohshima N
机构信息
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd, Ibaraki, Japan.
出版信息
Eur J Pharmacol. 1996 Sep 19;312(1):69-73. doi: 10.1016/0014-2999(96)00547-x.
We report here the synergistic antithrombotic effect of aurintricarboxylic acid in combination with a snake venom-derived disintegrin, triflavin, in a photochemically induced thrombosis model in rats. The time to initiation of thrombus was prolonged by i.v. bolus injection of aurintricarboxylic acid at 10 mg/kg. In contrast, time to occlusion was dose-dependently prolonged by both agents, this prolongation being significant with aurintricarboxylic acid at 10 mg/kg i.v. and with triflavin at more than 3 mg/kg i.v. Interestingly, the combination of aurintricarboxylic acid at 3 mg/kg i.v. and triflavin at 1 mg/kg i.v. prolonged not only the initiation of thrombus, but also the time to occlusion.
我们在此报告金精三羧酸与一种源自蛇毒的去整合素（三黄素）联合使用在大鼠光化学诱导血栓形成模型中的协同抗血栓作用。静脉推注10mg/kg金精三羧酸可延长血栓形成起始时间。相比之下，两种药物均剂量依赖性地延长了血管闭塞时间，静脉注射10mg/kg金精三羧酸和静脉注射超过3mg/kg三黄素时这种延长具有显著性。有趣的是，静脉注射3mg/kg金精三羧酸与静脉注射1mg/kg三黄素联合使用不仅延长了血栓形成起始时间，还延长了血管闭塞时间。
Zotero 插件