Savci V, Ulus I H
Department of Pharmacology, Uludag University Medical Faculty, Bursa, Turkey.
Eur J Pharmacol. 1996 Sep 12;311(2-3):153-61. doi: 10.1016/0014-2999(96)00424-4.
The effect of intracerebrovenricularly (i.c.v.) injected choline on blood pressure was investigated in rats made hypotensive by blocking peripheral alpha-adrenoceptors or autonomic ganglionic transmission. Choline (50-150 micrograms; i.c.v.) increased blood pressure in a dose-dependent manner and 150 micrograms of choline restored blood pressure to the resting level. The pressor response to choline was associated with an increase in plasma vasopressin levels. Pretreatment with mecamylamine (50 micrograms; i.c.v.), but not atropine (10 micrograms; i.c.v.), blocked both the pressor and vasopressin responses to i.c.v. choline. The vasopressin receptor antagonist, [beta-mercapto-beta,beta-cyclopenta-methylene-propionyl1,O-Me-T ry2,Arg8] vasopressin (10 micrograms/kg; i.v.), given 5 min after i.c.v. choline (150 micrograms), abolished the pressor effect of choline and blood pressure returned to the pre-choline levels. It is concluded that the precursor of acetylcholine, choline, can increase blood pressure and reverse hypotension in alpha-adrenoceptor or ganglionic transmission blocked rats, by increasing plasma vasopressin.
在通过阻断外周α-肾上腺素能受体或自主神经节传递而导致低血压的大鼠中，研究了脑室内（i.c.v.）注射胆碱对血压的影响。胆碱（50 - 150微克；i.c.v.）以剂量依赖性方式升高血压，150微克胆碱可使血压恢复到静息水平。胆碱的升压反应与血浆血管加压素水平升高有关。用美加明（50微克；i.c.v.）预处理可阻断对i.c.v.胆碱的升压和血管加压素反应，但阿托品（10微克；i.c.v.）预处理则不能。在i.c.v.注射胆碱（150微克）5分钟后静脉注射血管加压素受体拮抗剂[β-巯基-β,β-环戊亚甲基-丙酰基1,O-甲基-色氨酸2,精氨酸8]血管加压素（10微克/千克），可消除胆碱的升压作用，血压恢复到注射胆碱前的水平。结论是，乙酰胆碱的前体胆碱可通过增加血浆血管加压素，升高α-肾上腺素能受体或神经节传递受阻大鼠的血压并逆转低血压。
