掌跖角化牙周破坏综合征。外周血淋巴细胞亚群分析。

Papillon-Lefèvre syndrome. Analysis of peripheral blood lymphocyte subsets.

作者信息

Firatli E, Gürel N, Efeoğlu A

机构信息

Department of Periodontology, School of Dentistry, Istanbul School of Medicine, University of Istanbul, Turkey.

出版信息

J Clin Periodontol. 1996 Sep;23(9):823-5. doi: 10.1111/j.1600-051x.1996.tb00618.x.

DOI:10.1111/j.1600-051x.1996.tb00618.x

PMID:8891932

Abstract

We have studied the peripheral blood lymphocyte populations in our 6 patients (2 female and 4 male) with a mean age of 11.19 with Papillon-Lèfevre Syndrome (PLS) using adequate monoclonal antibodies and double coloured flow cytometry. Total B, T, CD4, CD8, CD29, CD45RA, NK, HLA-DR cells were studied. Total B, T, CD4 and CD8 lymphocytes were within normal limits. We have observed an increase in the CD29 lymphocytes and NK cells and a decrease in CD45RA lymphocytes. We think that these findings are important in explaining B lymphocyte activation and in the pathogenesis of the PLS.

摘要

我们使用合适的单克隆抗体和双色流式细胞术，对6例平均年龄为11.19岁的患有帕皮隆-勒费夫尔综合征（PLS）的患者（2名女性和4名男性）的外周血淋巴细胞群体进行了研究。研究了总B细胞、T细胞、CD4、CD8、CD29、CD45RA、自然杀伤（NK）细胞、人类白细胞抗原-DR（HLA-DR）细胞。总B细胞、T细胞、CD4和CD8淋巴细胞均在正常范围内。我们观察到CD29淋巴细胞和NK细胞增加，而CD45RA淋巴细胞减少。我们认为这些发现对于解释B淋巴细胞活化和PLS的发病机制具有重要意义。