Blanchet P
Ann Dermatol Venereol. 1978 Dec;105(12):1001-7.
Paroxystic vasomotor skin manifestations are provoked by various etiologies. Widespread or generalized vasomotor skin manifestations may be induced by a physiological reaction (emotinal flushing), by a drug (vasodilator drugs, antabuse, antidiabetic, sulfonamides), by a discharge of histamine (urticaria, mastocytosis) or by an hypersecretion of serotonin (dumping-syndrome, carcinoid syndrome). They may be caused by an endocrinopathy (menopause, hyperthyroidism, hypoglycaemia, medullary thyroid carcinoma, pheochromocytoma, endocrine pancreas, carcinoma). More rarely vasomotor troubles happen in homocystinuria, inhalation of a toxic (trichlorethylen, calcic cyanamid) and exceptionally in some immunohaematologic diseases. Main localized vasomotor skin manifestations observed are dermographism, facial flushing (Sluder's syndrome, cluster headaches, Frey's syndrome, Riley-Day's syndrome) and acral syndromes (Raynaud's phenomenon, erythromelalgia).
阵发性血管舒缩性皮肤表现由多种病因引起。广泛或全身性血管舒缩性皮肤表现可能由生理反应（情绪性潮红）、药物（血管扩张剂、戒酒硫、抗糖尿病药、磺胺类药物）、组胺释放（荨麻疹、肥大细胞增多症）或血清素分泌过多（倾倒综合征、类癌综合征）诱发。它们可能由内分泌病（更年期、甲状腺功能亢进、低血糖、甲状腺髓样癌、嗜铬细胞瘤、内分泌胰腺、癌）引起。血管舒缩性问题在高胱氨酸尿症、吸入毒物（三氯乙烯、氰氨化钙）时较少发生，在某些免疫血液学疾病中则极为罕见。观察到的主要局限性血管舒缩性皮肤表现有皮肤划痕症、面部潮红（斯路德综合征、丛集性头痛、弗雷综合征、赖利 - 戴综合征）和肢端综合征（雷诺现象、红斑性肢痛症）。
