双组分信号转导系统和磷酸烯醇式丙酮酸：碳水化合物磷酸转移酶系统在流感嗜血杆菌Rd感受态发育中的作用
Role of the two-component signal transduction and the phosphoenolpyruvate: carbohydrate phosphotransferase systems in competence development of Haemophilus influenzae Rd.
作者信息
Gwinn M L, Yi D, Smith H O, Tomb J F
机构信息
Department of Molecular Biology and Genetics, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA.
出版信息
J Bacteriol. 1996 Nov;178(21):6366-8. doi: 10.1128/jb.178.21.6366-6368.1996.
Abstract
Haemophilus influenzae Rd becomes competent for transformation by nutritional downshift or transient anaerobic growth through a process that requires cyclic AMP receptor protein and adenylate cyclase. Insertion mutations in crr or ptsI of the phosphoenolpyruvate:carbohydrate phosphotransferase system lowered transformation frequencies, and the effect was reversed by the addition of cyclic AMP. However, insertions into H. influenzae homologs of two-component signal transduction genes had no effect on competence.
摘要
流感嗜血杆菌Rd通过营养物质降档或短暂厌氧生长，经一个需要环磷酸腺苷受体蛋白和腺苷酸环化酶的过程而具备转化能力。磷酸烯醇式丙酮酸：碳水化合物磷酸转移酶系统的crr或ptsI中的插入突变降低了转化频率，添加环磷酸腺苷可逆转此效应。然而，插入到双组分信号转导基因的流感嗜血杆菌同源物中对感受态没有影响。
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