基于鼠白血病病毒的Tat诱导型长末端重复序列置换载体：一种用于抗人类免疫缺陷病毒基因治疗的新系统。
Murine leukemia virus-based Tat-inducible long terminal repeat replacement vectors: a new system for anti-human immunodeficiency virus gene therapy.
作者信息
Cannon P M, Kim N, Kingsman S M, Kingsman A J
机构信息
Retrovirus Molecular Biology Group, Department of Biochemistry, University of Oxford, United Kingdom.
出版信息
J Virol. 1996 Nov;70(11):8234-40. doi: 10.1128/JVI.70.11.8234-8240.1996.
Abstract
We have constructed new murine leukemia virus (MLV)-based vectors (TIN vectors) which, following integration, contain human immunodeficiency virus (HIV) type 1 U3 and R sequences in place of the MLV U3 and R regions. This provides, for the first time, single transcriptional unit retroviral vectors under the control of Tat. TIN vectors have several advantages for anti-HIV gene therapy applications.
摘要
我们构建了新型的基于鼠白血病病毒（MLV）的载体（TIN载体），这些载体在整合后，包含人类免疫缺陷病毒（HIV）1型的U3和R序列，取代了MLV的U3和R区域。这首次提供了在Tat控制下的单转录单位逆转录病毒载体。TIN载体在抗HIV基因治疗应用中有几个优点。
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