van Kooij R J, Looman C W, Habbema J D, Dorland M, te Velde E R
Department of Reproductive Medicine, University Hospital Utrecht, The Netherlands.
Fertil Steril. 1996 Nov;66(5):769-75. doi: 10.1016/s0015-0282(16)58634-8.
To investigate the relation between the implantation rate per embryo after replacement in IVF-ET in relation to female age.
Retrospective study using linear and biphasic models in a multivariate analysis.
Academic tertiary care institution.
INTERVENTION(S): In vitro fertilization-ET and determination of gestational sacs at 6 to 7 weeks of pregnancy buy ultrasound.
MAIN OUTCOME MEASURE(S): Implantation rate as defined by the number of gestational sacs per embryo replaced.
RESULT(S): Woman's age and embryo morphology were strongly related to the implantation rate, indication for IVF-ET and cycle rank number also were related significantly but less strongly. A linear model was built describing the decrease in implantation rate with age, resulting in a decrease of approximately 7%. A biphasic model was tested also and performed significantly better, resulting in a yearly decrease of > 20% after 37 years of age.
CONCLUSION(S): The most important independent factors related to the ability of embryos to implant are female age and embryo morphology. The best way to describe the relation with female age is biphasic model with a discontinuity at approximately 37 years of age.
探讨体外受精-胚胎移植（IVF-ET）中胚胎移植后每个胚胎着床率与女性年龄之间的关系。
在多变量分析中使用线性和双相模型的回顾性研究。
学术性三级医疗机构。
体外受精-胚胎移植，并在妊娠6至7周时通过超声确定妊娠囊。
以每个移植胚胎的妊娠囊数量定义的着床率。
女性年龄和胚胎形态与着床率密切相关，IVF-ET的指征和周期序号也有显著相关性，但相关性较弱。建立了一个描述着床率随年龄下降的线性模型，结果显示着床率下降约7%。还测试了双相模型，其表现明显更好，37岁以后每年下降超过20%。
与胚胎着床能力相关的最重要独立因素是女性年龄和胚胎形态。描述与女性年龄关系的最佳方法是在约37岁处有断点的双相模型。
