Ohshige A, Ito M, Koyama H, Maeda T, Yoshimura T, Okamura H
Department of Obstetrics and Gynecology, Kumamoto University School of Medicine, Japan.
Artery. 1996;22(3):115-24.
We examined the effects of estrogen and progesterone on the plasma platelet-activating factor (PAF)-acetylhydrolase activity and lipoprotein concentrations in men.
Ten healthy men received 6 days of oral mestranol (0.24 mg/day) followed by 6 days of oral norethisterone (20 mg/day). The PAF-acetylhydrolase activity and lipoprotein profiles were determined in each subject prior to and following mestranol loading and following norethisterone administration.
The mestranol caused a significant decrease in both the plasma PAF-acetylhydrolase activity and the low-density lipoprotein (LDL) cholesterol concentrations of 26.4% and 26.9%, respectively; norethisterone appeared to revert the PAF-acetylhydrolase activity and LDL cholesterol concentrations to the levels observed prior to mestranol loading. In addition, the plasma PAF-acetylhydrolase activity was positive correlated with the LDL cholesterol concentration (r = 0.58, P < 0.001).
The results of this study indicate that mestranol and norethisterone exert an effect on the plasma PAF-acetylhydrolase activity in men, possibly by influencing plasma LDL cholesterol concentrations.
我们研究了雌激素和孕激素对男性血浆血小板活化因子（PAF）-乙酰水解酶活性及脂蛋白浓度的影响。
10名健康男性先接受6天口服炔雌醇甲醚（0.24毫克/天），随后接受6天口服炔诺酮（20毫克/天）。在炔雌醇甲醚给药前、给药后以及炔诺酮给药后，测定每位受试者的PAF-乙酰水解酶活性和脂蛋白谱。
炔雌醇甲醚使血浆PAF-乙酰水解酶活性和低密度脂蛋白（LDL）胆固醇浓度分别显著降低26.4%和26.9%；炔诺酮似乎使PAF-乙酰水解酶活性和LDL胆固醇浓度恢复到炔雌醇甲醚给药前的水平。此外，血浆PAF-乙酰水解酶活性与LDL胆固醇浓度呈正相关（r = 0.58，P < 0.001）。
本研究结果表明，炔雌醇甲醚和炔诺酮可能通过影响血浆LDL胆固醇浓度对男性血浆PAF-乙酰水解酶活性产生影响。
