Elewski B E, Jones T, Zaias N
Mycology Reference Laboratory, University Center for Medical Mycology, University Hospitals of Cleveland, Ohio 44106-5028, USA.
Cutis. 1996 Oct;58(4):305-7.
The efficacy and safety of monotherapy with oxiconazole nitrate cream, 1 percent, a topical broadspectrum antifungal agent, were compared with those of combination therapy with oxiconazole nitrate cream, 1 percent, and fluticasone propionate cream, 0.05 percent, in a multicenter, randomized, double-blind, vehicle-controlled, parallel-group study of patients with inflammatory tinea pedis. Both combination therapy and monotherapy were associated with significantly greater proportions of mycologic and clinical cure, and a better global response than vehicle. An unexpected finding in this study was that more than 70 percent of patients with interdigital tinea pedis also had plantar or plantar plus vesiculobullous infection.
在一项针对炎症性足癣患者的多中心、随机、双盲、赋形剂对照、平行组研究中，对1%硝酸奥昔康唑乳膏（一种外用广谱抗真菌剂）单药治疗的疗效和安全性与1%硝酸奥昔康唑乳膏和0.05%丙酸氟替卡松乳膏联合治疗的疗效和安全性进行了比较。联合治疗和单药治疗均与真菌学和临床治愈率显著更高以及比赋形剂更好的整体反应相关。该研究中的一个意外发现是，超过70%的指间足癣患者同时伴有足底或足底加水疱大疱性感染。
