Nakanishi Y, Wakamatsu K, Nomoto Y, Kawasaki M, Takayama K, Yatsunami J, Tsuruta N, Hashimoto S, Hara N
Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka.
Intern Med. 1996 Aug;35(8):657-9. doi: 10.2169/internalmedicine.35.657.
We report two cases of empyema as a complication of the percutaneous instillation of antifungal drugs for pulmonary and pleural aspergillosis. Case 1 underwent percutaneous administration of amphotericin B and fluconazole for 2 months. Six months later, the patient was found to have an Aspergillus empyema with a bronchopleural fistula. Case 2 with pulmonary and pleural aspergillosis underwent percutaneous administration of amphotericin B for one month. Four months later, the patient underwent pleural drainage due to empyema. Pleural biopsy revealed pleural aspergillosis. In both cases, it was suggested that the preceding Aspergillus infection and percutaneous instillation of antifungals resulted in the development of empyema.
我们报告了两例因经皮注入抗真菌药物治疗肺和胸膜曲霉病而并发脓胸的病例。病例1经皮给予两性霉素B和氟康唑治疗2个月。6个月后，该患者被发现患有伴有支气管胸膜瘘的曲霉性脓胸。病例2患有肺和胸膜曲霉病，经皮给予两性霉素B治疗1个月。4个月后，该患者因脓胸接受了胸腔引流。胸膜活检显示胸膜曲霉病。在这两个病例中，提示先前的曲霉感染和经皮注入抗真菌药物导致了脓胸的发生。
