Bennett T O, Sugar J, Sahgal S
Arch Ophthalmol. 1977 Aug;95(8):1362-4. doi: 10.1001/archopht.1977.04450080072005.
A 54-year-old man was receiving allopurinol therapy to treat hyperuricemia that followed an inferior wall, myocardial infarction. After three weeks of allopurinol therapy, the patient developed signs and symptoms of toxic epidermal necrolysis that included pseudomembranous conjunctivitis with ulcerative lesions on the lids and conjunctiva, and punctate corneal staining with subsequent corneal abrasions. Treatment with topical antibiotics and artificial tears relieved the symptoms somewhat, but punctate staining and dry eyes persisted after 14 months of follow-up. Bilateral corneal ulcers developed and necessitated conjunctival flaps in each eye. Visual acuity in each eye was 20/40.
一名54岁男性因下壁心肌梗死后的高尿酸血症接受别嘌醇治疗。别嘌醇治疗三周后，患者出现中毒性表皮坏死松解症的体征和症状，包括伴有眼睑和结膜溃疡性病变的假膜性结膜炎，以及点状角膜染色并随后出现角膜擦伤。局部使用抗生素和人工泪液治疗在一定程度上缓解了症状，但随访14个月后点状染色和干眼症状仍持续存在。双侧角膜溃疡形成，每只眼睛都需要进行结膜瓣手术。每只眼睛的视力均为20/40。
