Geiger J D, Brumleve S J, Boelkins J N, Parmar S S
Aviat Space Environ Med. 1977 Aug;48(8):737-40.
The effects of prolonged exposure to a hyperbaric environment (21 ATA He-O2, 200 +/- 300 mm Hg O2, 32.5 +/- 1 degrees C) were investigated on the activity of rat liver drug-metabolizing enzyme systems, as monitored by O-dealkylation and N-dealkylation reactions. Continuous exposure of different groups of rats to a hyperbaric environment for 8, 22, 39, 57, or 84 d significantly increased the in vitro activity of drug-metabolizing enzymes in liver preparations obtained from rats subjected to prolonged exposures. The increase in the in vitro O-dealkylation of p-nitroanisole was selective; and the percent increases were 27, 146, 58, 40, 49, and 44 in liver preparations obtained from rats exposed continuously for 8, 22, 39, 57, 72, or 84 d, respectively. On the other hand, no statistically significant increase was observed in the in vitro activity of rat liver drug-metabolizing enzyme preparations during N-dealkylation of morphine and cocaine.
研究了长时间暴露于高压环境（21个绝对大气压的氦氧混合气、200±300毫米汞柱氧气、32.5±1摄氏度）对大鼠肝脏药物代谢酶系统活性的影响，通过O-脱烷基化和N-脱烷基化反应进行监测。将不同组大鼠连续暴露于高压环境8、22、39、57或84天，显著提高了从长时间暴露的大鼠获得的肝脏制剂中药物代谢酶的体外活性。对硝基苯甲醚的体外O-脱烷基化增加具有选择性；在连续暴露8、22、39、57、72或84天的大鼠肝脏制剂中，增加的百分比分别为27%、146%、58%、40%、49%和44%。另一方面，在吗啡和可卡因的N-脱烷基化过程中，大鼠肝脏药物代谢酶制剂的体外活性未观察到统计学上的显著增加。
