Jimenez-Bonilla J F, Carril J M, Quirce R, Gomez-Barquin R, Amado J A, Gutierrez-Mendiguchia C
Servicio de Medicina Nuclear, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
Nucl Med Commun. 1996 Sep;17(9):790-4. doi: 10.1097/00006231-199609000-00009.
We assessed cerebral blood flow in 78 diabetic patients (40 Type 1 and 38 Type 2) with no previous history of central nervous system disease using 99Tcm-hexamethylpropylene amine oxime (99Tcm-HMPAO) single photon emission tomography (SPET) and found areas of severe hypoperfusion in 36% of them. All cerebral anatomical regions showed abnormalities related to hypoperfusion, but they were most frequently seen in the fronto-temporal region, followed by the occipital and parietal regions. 99Tcm-HMPAO SPET has been shown to be able to detect subclinical alterations in blood flow in diabetes, a finding that may account for the high prevalence of cerebrovascular disease seen in these patients. This technique could, therefore, play an important role in future preventative strategies.
我们使用99锝-六甲基丙烯胺肟（99Tcm-HMPAO）单光子发射断层扫描（SPET）对78例既往无中枢神经系统疾病史的糖尿病患者（40例1型和38例2型）进行了脑血流评估，发现其中36%存在严重灌注不足区域。所有脑解剖区域均显示出与灌注不足相关的异常，但最常出现在额颞区域，其次是枕叶和顶叶区域。99Tcm-HMPAO SPET已被证明能够检测糖尿病患者血流中的亚临床改变，这一发现可能解释了这些患者中脑血管疾病的高患病率。因此，这项技术可能在未来的预防策略中发挥重要作用。
