Zagrean L, Vatasescu R, Oprica M, Nutiu O, Ferechide D
Department of Physiology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Rom J Physiol. 1995 Jan-Dec;32(1-4):39-44.
Cerebral ischemia and anoxia induce sequential changes that include ionic redistribution, alteration of enzimatic reactions governing metabolism and intracellular signaling. Despite high technology instrumentation including positron emission, tomography and magnetic resonance imaging used to unravel the intricacies of cerebral blood flow and metabolism, the electroencephalography (EEG) retains a useful place in the evaluation of processes induced by cerebral ischemia, especially in experimental conditions. We have investigated in this study EEG suppression and recovery following global cerebral ischemia, obtained by "four vessel occlusion model", reperfusion and anoxia. Both cerebral ischemia and anoxia have produced a sudden diminution of electrical brain activity and flat line was recorded after 8-10 sec. in the ischemic rats, but after 35-40 sec. in the anoxic rats. After same period of time (2 min) of ischemia and anoxia EEG recovery has been faster in the ischemic rat.
脑缺血和缺氧会引发一系列变化，包括离子重新分布、调控代谢和细胞内信号传导的酶促反应改变。尽管有正电子发射断层扫描和磁共振成像等高科技仪器用于揭示脑血流和代谢的复杂性，但脑电图（EEG）在评估脑缺血引发的过程中仍占有一席之地，尤其是在实验条件下。在本研究中，我们通过“四血管闭塞模型”研究了全脑缺血、再灌注和缺氧后脑电图的抑制和恢复情况。脑缺血和缺氧均导致脑电活动突然减弱，缺血大鼠在8 - 10秒后记录到平线，而缺氧大鼠在35 - 40秒后记录到平线。在相同时长（2分钟）的缺血和缺氧后，缺血大鼠的脑电图恢复更快。
