Williams I M, Mortimer A J, McCollum C N
Department of Surgery, University Hospital of South Manchester, West Didsbury, Manchester, U.K.
Eur J Vasc Endovasc Surg. 1996 Oct;12(3):263-71. doi: 10.1016/s1078-5884(96)80243-7.
A recent development has been the resurgence of interest in the concept of near-infrared light spectroscopy as a method of monitoring cerebral perfusion. Although this technique has been in use for 40 years, the principle has been primarily employed in peripheral pulse oximetry. Infrared light of wavelengths 600-1300 nanometres (nm) penetrate human tissue to a depth of several centimetres. Within the human brain this light is attenuated by the chromophores oxyhaemoglobin, deoxyhaemoglobin and also oxidised cytochrome a3. Positioning a near-infrared light source and a photodetector in a side by side configuration detects light attenuated and reflected in a parabolic path through the scalp, skull and brain tissue.
最近的一项进展是，人们对近红外光光谱学作为一种监测脑灌注的方法重新产生了兴趣。尽管这项技术已经使用了40年，但其原理主要应用于外周脉搏血氧测定法。波长为600 - 1300纳米（nm）的红外光可穿透人体组织达几厘米深。在人类大脑中，这种光会被发色团氧合血红蛋白、脱氧血红蛋白以及氧化细胞色素a3衰减。将一个近红外光源和一个光电探测器并排放置，可检测在通过头皮、颅骨和脑组织的抛物线形路径中衰减和反射的光。
