Myers M G
Division of Cardiology, Sunnybrook Health Science Centre, Toronto, Ontario, Canada.
Am J Hypertens. 1996 Oct;9(10 Pt 2):76S-82S; discussion 87S-90S. doi: 10.1016/0895-7061(96)00267-1.
The trough-to-peak (T:P) ratio is a measure of a drug's antihypertensive effects over a standard dosing interval. The T:P ratio was introduced by regulatory authorities without any details on how it was to be derived from clinical trial data. Differences in study design (sequential versus cross-over), techniques for recording blood pressure, methods of correcting for placebo responses, timing and duration of peak and trough effects, activity status of patients, use of responders only versus all subjects, and duration of antihypertensive therapy have made it difficult to interpret the clinical relevance of much of the existing data on the T:P ratio. Minimum standards for obtaining the T:P ratio over a 24 h dosing interval are proposed for use in future studies in order to obtain more precise and reproducible T:P ratios and to compare differences between compounds with greater reliability.
谷峰（T:P）比值是衡量药物在标准给药间隔内降压效果的指标。监管机构引入了T:P比值，但未详细说明如何从临床试验数据中得出该比值。研究设计（序贯试验与交叉试验）、血压记录技术、安慰剂反应校正方法、峰效应和谷效应的时间及持续时间、患者的活动状态、仅使用反应者与所有受试者、以及降压治疗持续时间等方面的差异，使得很难解读现有许多关于T:P比值的数据的临床相关性。建议采用在24小时给药间隔内获取T:P比值的最低标准，用于未来研究，以便获得更精确和可重复的T:P比值，并更可靠地比较不同化合物之间的差异。
