Barr M L, Schenkel F A, Cohen R G, Chan K M, Marboe C C, Hagen J A, Barbers R G, Starnes V A
Division of Cardiothoracic Surgery, University of Southern California School of Medicine, Los Angeles 90033-4612, USA.
Artif Organs. 1996 Oct;20(10):1110-1. doi: 10.1111/j.1525-1594.1996.tb00645.x.
As the recipient list for patients requiring lung transplantation continues to increase, cadaveric donor lung availability has remained static. Our experience with utilizing lobes from living related donors for bilateral pulmonary transplantation in 20 patients has yielded a 75% survival at 1 year follow-up. Morbidity and mortality have been predominately due to infection. Rejection episodes have been mild and unilateral and have responded to augmented corticosteroids. Pulmonary function tests in the recipients tend to improve steadily during the first year postoperatively, and the patients have excellent functional capacity. There have been no significant complications in the donors. On the basis of our clinical experience, we have found that bilateral lobar transplantation utilizing living related donors has resulted in organ availability that can be lifesaving in critically ill patients and can provide a good alternative in certain noncritical, deteriorating patients.
随着需要肺移植的患者受者名单持续增加，尸体供肺的可获得性却一直停滞不前。我们利用亲属活体供者的肺叶为20例患者进行双侧肺移植的经验显示，在1年的随访期内生存率为75%。发病率和死亡率主要归因于感染。排斥反应发作轻微且为单侧，对增加剂量的皮质类固醇有反应。受者的肺功能测试在术后第一年往往稳步改善，患者具有良好的功能状态。供者未出现重大并发症。基于我们的临床经验，我们发现利用亲属活体供者进行双侧肺叶移植可使器官可供利用，这对危重症患者可能是救命的，并且可为某些非危重症、病情恶化的患者提供一个良好的替代方案。
