Effects of ubiquinone enriched diet on deterioration of mitochondrial respiratory function caused by fried beef derived mutagenic factor in rats.

2-Amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP), a potent mutagenic agent produced during thermal processing of meats, shows detrimental effects on mitochondrial respiratory function. Effects of dietary ubiquinone-10 was examined on PhIP-induced mitochondrial respiratory dysfunction in rats. Rats fed with 0.2% ubiquinone-10 diet mitigated the PhIP-induced decrease in mitochondrial complex I activities observed in rat heart, diaphragm, and psoai major. Therefore, dietary anti-oxidants such as ubiquinone-10 could cancel out the unfavorable effects of PhIP and contribute to the preservation of mitochondrial function.