Mueck A O, Seeger H, Lippert T H
Int J Clin Pharmacol Ther. 1996 Oct;34(10):424-6.
Cardiovascular effects of estrogens have been shown to be of great clinical importance treating patients with hormonal replacement therapy or using oral contraceptives. To test one nongenomic mechanism of direct vascular action, the calcium-antagonistic effect of natural and synthetic estrogens was investigated in cell cultures of human vascular muscle cells. 17 beta-estradiol significantly inhibited calcium influx at the concentrations of 10(-6) and 10(-7) M in resting and activated cells. Neither the natural estrogens, estrone, and estriol nor the synthetic estrogens, 17 alpha-estradiol and 17 alpha-ethinylestradiol, significantly changed calcium homeostasis in these cells. The results suggest that the vasodilatory effect of 17 beta-estradiol, seen with hormone substitution in postmenopausal women, could be mediated at least partly via influence on calcium homeostasis.
雌激素对心血管的影响在激素替代疗法治疗患者或使用口服避孕药时已显示出重要的临床意义。为了测试一种直接血管作用的非基因组机制，在人血管平滑肌细胞培养物中研究了天然和合成雌激素的钙拮抗作用。在静息和激活的细胞中，17β-雌二醇在10^(-6)和10^(-7) M浓度时显著抑制钙内流。天然雌激素雌酮和雌三醇以及合成雌激素17α-雌二醇和17α-乙炔雌二醇均未显著改变这些细胞中的钙稳态。结果表明，绝经后妇女激素替代治疗中所见的17β-雌二醇的血管舒张作用可能至少部分是通过对钙稳态的影响来介导的。
