Ward R H, Whyley G A, Fairweather D V, Allen E I, Chard T
Br J Obstet Gynaecol. 1977 May;84(5):363-9. doi: 10.1111/j.1471-0528.1977.tb12600.x.
Serial estimations were made in plasma of 17beta-oestradiol (E2), progesterone and human placental lactogen (HPL) in 43 patients and of human chorionic gonadotrophin (HCG) in 34 patients during mid-trimester abortions induced with intra-amniotic prostaglandin F2alpha (PGF2alpha. Mean plasma concentrations of all the hormones showed a progressive fall after PGF2alpha. There was no relationship between the fall in levels of progesterone, HPL and HCG and the induction-abortion interval, signs of fetal distress or of intrauterine fetal death. Both the control level and the rate of fall of E2 were related to the induction-abortion interval and a rapid decline preceded intrauterine fetal death. The relationships of the progesterone/E2 ratio and the amniotic fluid volume/progesterone ratio to the induction-abortion interval were examined. The variation in the time at which significant falls in the concentration of individual hormones occurred was probably related to their respective half-lives in plasma.
对43例患者的血浆进行了17β-雌二醇（E2）、孕酮和人胎盘催乳素（HPL）的系列测定，对34例患者在羊膜腔内注射前列腺素F2α（PGF2α）引产中期妊娠期间进行了人绒毛膜促性腺激素（HCG）的系列测定。PGF2α注射后，所有激素的平均血浆浓度均呈逐渐下降趋势。孕酮、HPL和HCG水平的下降与引产间隔、胎儿窘迫或宫内胎儿死亡迹象之间没有关系。E2的对照水平和下降速率均与引产间隔有关，且在宫内胎儿死亡前迅速下降。研究了孕酮/E2比值和羊水体积/孕酮比值与引产间隔的关系。个体激素浓度显著下降发生时间的变化可能与其在血浆中的各自半衰期有关。
