Puri C P, Rahman S A, Jain A K, Bhaduri R, Singh C M, Hingorani V, Laumas K R
Prostaglandins. 1976 May;11(5):905-23. doi: 10.1016/0090-6980(76)90197-0.
The serum levels of estradiol-17beta, progesterone and HPL have been estimated by specific radioimmunoassay in thirty women undergoing abortion with 15-methyl-PGF2alpha given by intra-amniotic, extra-amniotic or intra-muscular route. A significant decline in the levels of these hormones was observed in 27 cases in which the pregnancy was terminated. However, in the remaining three cases, 15-methyl-PGF2alpha was found to be unsuccessful, and no significant change in the hormone levels was evident. The decline in these hormones was more marked by intra-muscular route, than that observed by the other routes. The pattern of estradiol-17beta decline was more consistent when compared with progesterone and HPL. The levels of progesterone and HPL, in a few cases, rather showed an increase in the initial hours of 15-methyl-PGF2alpha administration before the decline began and this pattern was more prominent on extra-amniotic administration. In general, the decline in the hormone levels was slower in cases which took longer time for abortion than cases with shorter induction-abortion time (IAT). The decline in estradiol-17beta levels was about 65% at six hour of intra-muscular administration of 15-methyl-PGF2alpha, whereas the corresponding fall with intra-amniotic and extra-amniotic routes was 29 and 22%, respectively. However, the net drop in its levels during IAT was not significantly different (range 70 to 80%) by the three routes. About 38% fall in progesterone levels was observed at six hour of intra-muscular administration whereas, by intra-amniotic the fall was 19%. The net decline in progesterone levels, during IAT, was in the range of 46 to 60% by the three routes. Similarly, intra-muscular 15-methyl-PGF2alpha evoked a sharper decline in HPL levels as compared with other routes. The total decline during IAT was 58 to 66%. The results, thus indicated that the abortion with 15-methyl-PGF2alpha was associated with a fall in the serum hormone levels, which could be resultant effect of alterations in the hormone production by the foeto-placental unit. This along with the uterine contractions may play a significant role in the abortifacient action of 15-methyl-PGF2alpha.
采用特异性放射免疫分析法，对30例接受流产的妇女进行了血清雌二醇-17β、孕酮和人胎盘催乳素（HPL）水平的测定。这些妇女通过羊膜腔内、羊膜腔外或肌肉注射途径给予15-甲基前列腺素F2α。在27例妊娠终止的病例中，观察到这些激素水平显著下降。然而，在其余3例中，发现15-甲基前列腺素F2α引产未成功，激素水平无明显变化。与其他途径相比，肌肉注射途径导致这些激素水平下降更为明显。与孕酮和HPL相比，雌二醇-17β水平下降模式更为一致。在少数病例中，孕酮和HPL水平在开始下降前的最初几个小时内反而有所升高，这种模式在羊膜腔外给药时更为突出。一般来说，流产所需时间较长的病例中，激素水平下降速度比引产-流产时间（IAT）较短的病例慢。肌肉注射15-甲基前列腺素F2α 6小时后，雌二醇-17β水平下降约65%，而羊膜腔内和羊膜腔外途径相应的下降分别为29%和22%。然而，在IAT期间，其水平的净下降在三种途径中无显著差异（范围为70%至80%）。肌肉注射6小时后，孕酮水平下降约38%，而羊膜腔内注射下降为19%。在IAT期间，孕酮水平的净下降在三种途径中为46%至60%。同样，与其他途径相比，肌肉注射15-甲基前列腺素F2α引起HPL水平下降更为明显。IAT期间的总下降为58%至66%。因此，结果表明，15-甲基前列腺素F2α流产与血清激素水平下降有关，这可能是胎儿-胎盘单位激素产生改变的结果。这与子宫收缩一起可能在15-甲基前列腺素F2α的堕胎作用中起重要作用。
