Argiris A, Maris T, Papavasiliou G, Gouliamos A, Papavasiliou C
Department of Radiology, Areteion University Hospital, Athens, Greece.
Magn Reson Imaging. 1996;14(6):633-8. doi: 10.1016/0730-725x(96)00058-6.
The effect of localized radiotherapy on vertebral bone marrow was demonstrated in two patients using quantitative MRI studies with pixel-by-pixel measurement of T2 relaxation times with generation of T2 images. Conventional T1-weighted spin-echo images were obtained as well. Irradiated vertebral bone marrow was found to have longer T2 relaxation times than the neighboring nonirradiated bone marrow. These changes corresponded to the increased signal intensity on T1-weighted images and to the field of radiotherapy and were noted 2.5 to 32 mo after radiotherapy. Radiologists should be aware of the increased T2 relaxation times in irradiated bone marrow to correctly assess spinal disorders in irradiated patients. The reported T2 changes may reflect the abundance of adipose cells that proliferate in bone marrow after radiotherapy, or may indicate an additional histological change, such as bone marrow necrosis or edema. Conclusive histological proof remains to be obtained.
通过对两名患者进行定量MRI研究，逐像素测量T2弛豫时间并生成T2图像，证实了局部放疗对椎体骨髓的影响。同时也获取了传统的T1加权自旋回波图像。发现接受放疗的椎体骨髓的T2弛豫时间比相邻未接受放疗的骨髓更长。这些变化与T1加权图像上信号强度增加以及放疗区域相对应，在放疗后2.5至32个月被观察到。放射科医生应意识到放疗后骨髓中T2弛豫时间增加，以便正确评估接受放疗患者的脊柱疾病。所报道的T2变化可能反映了放疗后骨髓中增殖的脂肪细胞数量增加，或者可能表明存在其他组织学变化，如骨髓坏死或水肿。仍有待获得确凿的组织学证据。
