Ramirez L F
Department of Psychiatry, Case Western Reserve University, OH, USA.
Mt Sinai J Med. 1996 Oct-Nov;63(5-6):330-1.
It has been reported anecdotically that patients from Latin America need less medication than Anglo patients for the treatment of psychiatric disorders. These clinical observations have been questioned because of the character of the reports. However, ethnic differences in pharmacokinetics and pharmacodynamics are known to cause clinically observed differences in the effects of certain drugs. After investigation, such effects have been found to be pronounced in Asians, but few studies have been conducted with Hispanics. Fortunately, several studies are underway in Latin America, as reviewed in this brief report.
有轶事报道称,拉丁美洲的患者在治疗精神疾病时所需的药物比盎格鲁患者少。由于这些报道的性质,这些临床观察受到了质疑。然而,已知药代动力学和药效学方面的种族差异会导致某些药物的临床效果出现差异。经过调查,发现这种差异在亚洲人身上较为明显,但针对西班牙裔的研究较少。幸运的是,正如本简要报告中所综述的,拉丁美洲正在进行几项研究。