通过超敏检测法在女性样本中检测前列腺特异性抗原。
Prostate-specific antigen detection by ultrasensitive assay in samples from women.
作者信息
Filella X, Molina R, Alcover J, Menéndez V, Giménez N, Jo J, Carretero P, Ballesta A M
机构信息
Department of Clinical Biochemistry (Unit of Cancer Research), Hospital Clínic i Provincial, Barcelona, Spain.
出版信息
Prostate. 1996 Nov;29(5):311-6. doi: 10.1002/(SICI)1097-0045(199611)29:5<311::AID-PROS6>3.0.CO;2-C.
BACKGROUND
The Prostate Specific Antigen (PSA) has been characterized as a specific prostate marker. Recent studies have indicated the existence of a PSA of nonprostatic origin detected in lactating women and breast tumors.
METHODS
We have evaluated the presence of PSA by an ultrasensitive assay (COBAS CORE) in 252 serum and non serum samples from women.
RESULTS
The results demonstrate the presence of PSA in 100% of the breast secretions, 81% of the breast cysts, 80% of the bronchoalveolar lavage fluids and 71% of the cytosols of breast cancer. Likewise, PSA was detected in 14% of the sera evaluated, although the concentrations were always lower than 0.5 ng/ml.
CONCLUSIONS
We conclude that PSA should not continue being considered as the specific prostate tissue marker although, given that the serum concentrations detected are very low, they do appear to interfere to a minimum extent in the usefulness of PSA as a tumor marker.
背景
前列腺特异性抗原（PSA）已被确定为一种特异性前列腺标志物。最近的研究表明，在哺乳期妇女和乳腺肿瘤中检测到了非前列腺来源的PSA。
方法
我们采用超灵敏检测法（COBAS CORE）对252份女性血清和非血清样本中的PSA进行了评估。
结果
结果显示，100%的乳腺分泌物、81%的乳腺囊肿、80%的支气管肺泡灌洗液以及71%的乳腺癌细胞溶质中均存在PSA。同样，在14%的评估血清中检测到了PSA，不过其浓度始终低于0.5纳克/毫升。
结论
我们得出结论，尽管检测到的血清浓度非常低，似乎对PSA作为肿瘤标志物的效用干扰极小，但PSA不应再被视为特异性前列腺组织标志物。
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