Kato M, Asaka M, Kudo M, Sukegawa M, Katagiri M, Koshiyama T, Kagaya H, Nishikawa K, Hokari K, Takeda H, Sugiyama T
Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
Aliment Pharmacol Ther. 1996 Oct;10(5):821-7. doi: 10.1046/j.1365-2036.1996.52194000.x.
The effect of lansoprazole plus amoxycillin on curing Helicobacter pylori infection and peptic ulcer recurrence was evaluated.
The study group was composed of 68 patients with gastric ulcers and 51 with duodenal ulcers, all were H. pylori-positive. The participants were assigned at random to the lansoprazole alone group (lansoprazole 30 mg o.m. for 6 or 8 weeks) or the lansoprazole plus amoxycillin group (lansoprazole alone regimen plus amoxycillin at 500 mg q.d.s. concomitantly for the first 2 weeks). Healed patients were not given maintenance treatment with acid secretion inhibitors. The cure rate for H. pylori infection and the ulcer recurrence rate after 1 year were investigated.
The cure rate for H. pylori infection was 4.2% in patients receiving lansoprazole alone and 38.5% in patients receiving lansoprazole plus amoxycillin (P < 0.01) for gastric ulcers, and 0% in patients receiving lansoprazole alone and 61.9% in patients receiving lansoprazole plus amoxycillin (P < 0.001) for duodenal ulcers. The recurrence rate was 42.3% in patients receiving lansoprazole alone and 28.6% in patients receiving lansoprazole plus amoxycillin for gastric ulcers, and 66.7% for patients receiving lansoprazole alone and 11.1% for patients receiving lansoprazole plus amoxycillin (P < 0.001) for duodenal ulcers. None of the patients with gastric or duodenal ulcers cured of H. pylori infection had a recurrence.
Concomitant use of lansoprazole and amoxycillin increased the curative effects on H. pylori infection. However, the cure rates with this regimen remained inadequate.
评估兰索拉唑联合阿莫西林对幽门螺杆菌感染的治愈效果及消化性溃疡复发情况。
研究组由68例胃溃疡患者和51例十二指肠溃疡患者组成，均为幽门螺杆菌阳性。参与者被随机分配至单纯兰索拉唑组（兰索拉唑30毫克，口服，持续6或8周）或兰索拉唑联合阿莫西林组（在单纯兰索拉唑治疗方案基础上，前2周加用阿莫西林500毫克，每日4次）。溃疡愈合的患者未给予酸分泌抑制剂维持治疗。观察1年后幽门螺杆菌感染治愈率及溃疡复发率。
胃溃疡患者中，单纯使用兰索拉唑的幽门螺杆菌感染治愈率为4.2%，联合使用兰索拉唑和阿莫西林的治愈率为38.5%（P<0.01）；十二指肠溃疡患者中，单纯使用兰索拉唑的幽门螺杆菌感染治愈率为0%，联合使用兰索拉唑和阿莫西林的治愈率为61.9%（P<0.001）。胃溃疡患者中，单纯使用兰索拉唑的复发率为42.3%，联合使用兰索拉唑和阿莫西林的复发率为28.6%；十二指肠溃疡患者中，单纯使用兰索拉唑的复发率为66.7%，联合使用兰索拉唑和阿莫西林的复发率为11.1%（P<0.001）。幽门螺杆菌感染治愈的胃溃疡或十二指肠溃疡患者均未复发。
兰索拉唑与阿莫西林联合使用可提高幽门螺杆菌感染的治愈率。然而，该治疗方案的治愈率仍不充分。
